Role of TRAF1 in the development and progression of chronic lymphocytic leukemia.
Description
Chronic Lymphocytic Leukemia (CLL) is the most common leukemia in the Western world, and it is characterized by the gradual accumulation of quiescent, apoptosis resistant, B cells. Although CLL is seemingly a very uniform disease, new molecular data have highlighted unexpected heterogeneity among patients. A need exists to identify the critical modulators of CLL cell growth and survival towards the goal of identifying new targets for therapeutic invention.
Results from our laboratory have shown that alterations of the normal expression levels of different members of the TRAF family in lymphocytes are causative of disease, including leukemia/lymphoma. In this project, we propose to study the specific role of TRAF1 in the immune response and in the development and progression of CLL. Our results strongly suggest that TRAF1 is overexpressed in CLL cells from patients, and that this overexpression might have a key role in the etiology of CLL. Our results also suggest that TRAF1 might be a target for pharmacology development. We propose to elucidate the role of TRAF1 in B cell physiology and function and whether its constitutive expression in B cells predisposes to CLL/SLL in mice.
The aim will be to submit a project under the next call MARIE CURIE, therefore we require researchers from outside Spain.
Nr of positions available : 1
Research Fields
Biological sciences
Career Stage
Experienced researcher or 4-10 yrs (Post-Doc)
Research Profile
Recognised Researcher (R2)
Benefits
The Instituto de Investigaciones Biomédicas “Alberto Sols” is dedicated to discovering the fundamental molecular causes of disease and to translate our research to clinics. The Institute is placed in downtown Madrid and is part of the “Campus of Excellence” CSIC/UAM, holding state of the art research facilities and laboratories.
Comment/web site for additional job details
Additional information on the group:
http://www.iib.uam.es/persona?id=jmzapata
http://www.iib.uam.es/grupo?id=jmzapata_lab
