The Melanoma Group, within the Molecular Oncology Programme, is seeking for a postdoctoral fellow for an ongoing funded project aiming to address the crosstalk between melanoma cells and their microenvironment in the development of metastasis.
- PhD in Molecular Biology, Chemistry, Biotechnology or related disciplines.
- Hands on experience in the culture and analysis of tumor cells, particularly in the context of cell proliferation and cell survival. Lentiviral-based loss or gain of function in tumor cells (including, but not limited to shRNA and CRISPR/Cas9).
- Knowledge on vesicular trafficking (endo/exocytosis) and expertise in immunology or immunotherapy in animal models would be positively evaluated.
- Technical skills:
Mechanistic studies of stress-related programmes in cancer (apoptosis, autophagy, metabolic dysfunction). Background in histological techniques (immunohistochemistry, immunofluorescence). Techniques for isolation of immune cells (e.g. T cells, macrophages, dendritic cells) from tumors, peripheral blood, liver and spleen would be positively evaluated. Ability to isolate and characterize intracellular and secreted proteins (in soluble or exosome-containing fractions).
- Fluency in English.
- The opportunity to be part of one of the few European Cancer Research Centres of excellence.
- An excellent working, multidisciplinary environment.
- Competitive salary.
- Contract linked to a project.
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